Anti-HIV-1 activity of Sargassum swartzii a marine brown alga
نویسندگان
چکیده
Methods The HIV inhibitory activity of aqueous and methanolic extracts of S. swartzii was determined on laboratory adapted strains of HIV-1 clades C and A by indirectly measuring reduction in HIV-1 gag p24 antigen levels and inhibition of HIV-1 RT activity in supernatants of virus infected donor peripheral blood mononuclear cell (PBMC) cultures grown in varying concentrations of the extracts. Phytochemical analysis and cytotoxicity of the extracts was also undertaken.
منابع مشابه
Green Synthesis of Silver Nanoparticles Using Marine Brown Algae Sargassum
The present study was aimed to optimize the protocol for the synthesis of silver nanoparticles using aqueous extracts of Sargassum swartzii (Turner) C.Agardh and evaluate cytotoxic potetnials using brine shrimp bio-assay activity and Trypan blue dye exclusion method. The reduction of pure Ag+ ions was monitored by measuring the UV-Vis spectrum of the solution at 200-900 nm using Shimadzu spectr...
متن کاملPhytochemical Characterization of Marine Macro Alga Sargassum polycystem, Molecular Docking, and In Vitro Anti-bacterial Activity against Psuedomonas aeruginosa
Marine macro algae are useful to mankind as food, biofertilizer, and source of bioactive compounds such as agar-agar, alginates, and carrageenan. The aim of this study was to explore the phytochemicals, and the antibacterial activity of the marine alga Sargassum polycystem. The marine alga was subjected to ethanolic and methanolic extractions. The preliminary screening for phytochemicals showed...
متن کاملComparison of Antioxidant Activity and Total Phenolic Contents of some Persian Gulf Marine Algae
Background: Marine algae, especially brown species, produce a wide range of metabolites with various biological activities. Objective: Since marine algae are rich source of dietary fibers, minerals, proteins, vitamins and phenolic components with antioxidant effect, in addition to the rule of oxidative stress in pathogenesis of chronic diseases, the aim of this study was to investigate possib...
متن کاملFibrinolytic Compounds Isolated from a Brown Alga, Sargassum fulvellum
Two of bioactive natural products were founded in a brown alga, Sargassum fulvellum. After isolation and purification, the molecular structures of these two products were investigated by NMR spectroscopy and GC-mass spectroscopy. The two compounds were identified to be 1-O-palmitoyl-2-O-oleoyl-3-O-(alpha-D-glucopyranosyl)-glycerol (POGG) and 1-O-myristoyl-2-O-oleoyl-3-O-(alpha-D-glucopyranosyl)...
متن کاملCytotoxic activity of some marine brown algae against cancer cell lines.
The aim of this study was to investigate the in vitro cytotoxic activity of total extract of MeOH (70%) and partition fractions of hexan, chloroform (CHCL3), ethylacetate (EtOAc) and MeOH-H2O of brown algae species (Sargassum swartzii, Cystoseira myrica, Colpomenia sinuosa) found in the Persian Gulf against in different cell lines including HT-29, Caco-2, T47D, MDA-MB468 and NIH 3T3 cell lines ...
متن کامل